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Bacteria namesPreferred ++Acceptable + Possibly affective ± Usually susceptible
Enterococcus faecalisPenicillin (add gentamicin or other aminoglycoside)Amoxicillin/ Clavulanate
Enterococcus faecalisAmpicillin/ Amoxicillin (add gentamicin or other aminoglycoside)Vancomycin (add gentamicin or other aminoglycoside)
Enterococcus faecalisLinezolid
Enterococcus faecalisDaptomycin
Enterococcus faeciumPenicillin (add gentamicin or other aminoglycoside)Amoxicillin/ Clavulanate
Enterococcus faeciumAmpicillin/ Amoxicillin (add gentamicin or other aminoglycoside)Vancomycin (add gentamicin or other aminoglycoside)
Enterococcus faeciumLinezolid
Enterococcus faeciumDaptomycin
Nocardia sppLinezolidAmoxicillin/ ClavulanateTMP/STX
Nocardia sppMeropenem
Nocardia sppAmikacin
Staphylococcus, coagulase negativeVancomycinClindamycinMethicillin/ Oxacillin
Staphylococcus, coagulase negativeLinezolid Cefazolin/ Cephalexin
Staphylococcus, coagulase negativeDaptomycin
Staphylococcus, coagulase negativeCeftaroline
Staphylococcus aureus, methicillin-susceptibleMethicillin/ OxacillinClindamycin
Staphylococcus aureus, methicillin-susceptibleCefazolin/ Cephalexin
Staphylococcus aureus, methicillin-susceptibleVancomycin
Staphylococcus aureus, methicillin-susceptibleLinezolid
Staphylococcus aureus, methicillin-susceptibleDaptomycin
Staphylococcus aureus, methicillin-susceptibleCeftaroline
Staphylococcus aureus, methicillin-resistantVancomycin
Staphylococcus aureus, methicillin-resistantClindamycin
Staphylococcus aureus, methicillin-resistantLinezolid
Staphylococcus aureus, methicillin-resistantDaptomycin
Staphylococcus aureus, methicillin-resistantCeftaroline
Streptococcus pneumoniaePenicillinMethicillin/ Oxacillin
Streptococcus pneumoniaeAmpicillin/ Amoxicillin Vancomycin
Streptococcus pneumoniaeAmoxicillin/ ClavulanateClindamycin
Streptococcus pneumoniaeCefazolin/ CephalexinDaptomycin
Streptococcus pneumoniaeLinezolid
Streptococcus pneumoniaeCeftaroline
Streptococcus pyogenesPenicillin Vancomycin
Streptococcus pyogenesAmpicillin/ Amoxicillin Linezolid
Streptococcus pyogenesAmoxicillin/ Clavulanate
Streptococcus pyogenesMethicillin/ Oxacillin
Streptococcus pyogenesCefazolin/ Cephalexin
Streptococcus pyogenesClindamycin
Streptococcus pyogenesDaptomycin
Streptococcus pyogenesCeftaroline
Acinetobacter sppCeftriaxone
Acinetobacter sppCeftazidime/ Avibactam
Acinetobacter sppCeftazidime
Acinetobacter sppCefepime
Acinetobacter sppMeropenem/ Imipenem
Acinetobacter sppPiperacillin/ Tazobactam
Acinetobacter sppTMP/SMX
Acinetobacter sppCiprofloxacin
Citrobacter sppCeftazidime/ AvibactamCefuroxime
Citrobacter sppCefepimeCeftriaxone
Citrobacter sppMeropenem/ ImipenemCeftazidime
Citrobacter sppTMP/SMX Piperacillin/ Tazobactam
Citrobacter sppCiprofloxacinGentamicin
Enterobacter sppCeftazidime/ AvibactamCeftriaxoneCefuroxime
Enterobacter sppCefepimeCeftazidime
Enterobacter sppMeropenem/ ImipenemPiperacillin/ Tazobactam
Enterobacter sppTMP/SMX Gentamicin
Enterobacter sppCiprofloxacin
Escherichia coliCefuroxime (if ESBL producing E.coli this is resistant) Ampicillin/ Amoxicillin
Escherichia coliCeftriaxone (if ESBL producing E.coli this is resistant)Amoxicillin/ Clavulanate
Escherichia coliCeftazidime/ Avibactam Cefazolin/ Cephalexin
Escherichia coliCeftazidime (if ESBL producing E.coli this is resistant)TMP/SMX
Escherichia coliCefepimeGentamicin
Escherichia coliMeropenem/ Imipenem
Escherichia coliPiperacillin/ Tazobactam
Escherichia coliCiprofloxacin
Haemophilus influenzaeAmoxicillin/ Clavulanate Ampicillin/ Amoxicillin (if beta-lactamase producing this will be resistant)Gentamicin
Haemophilus influenzaeCefuroximeCefazolin/ Cephalexin
Haemophilus influenzaeCeftriaxone
Haemophilus influenzaeCeftazidime/ Avibactam
Haemophilus influenzaeCeftazidime
Haemophilus influenzaeCefepime
Haemophilus influenzaeMeropenem/ Imipenem
Haemophilus influenzaePiperacillin/ Tazobactam
Haemophilus influenzaeTMP/SMX
Haemophilus influenzaeCiprofloxacin
Klebsiella sppCefuroxime Cefazolin/ Cephalexin
Klebsiella sppCeftriaxone
Klebsiella sppCeftazidime/ Avibactam
Klebsiella sppCeftazidime
Klebsiella sppCefepime
Klebsiella sppMeropenem/ Imipenem
Klebsiella sppPiperacillin/ Tazobactam
Klebsiella sppTMP/SMX
Klebsiella sppCiprofloxacin
Klebsiella sppGentamicin
Neisseria meningitidisAmpicillin/ Amoxicillin Cefuroxime
Neisseria meningitidisAmoxicillin/ ClavulanateCeftazidime/ Avibactam
Neisseria meningitidisCeftriaxoneCeftazidime
Neisseria meningitidisCefepimeCiprofloxacin
Neisseria meningitidisMeropenem/ Imipenem
Neisseria meningitidisPiperacillin/ Tazobactam
Pseudomonas aeruginosaCeftazidime/ Avibactam Ceftazidime
Pseudomonas aeruginosaCefepimeGentamicin
Pseudomonas aeruginosaMeropenem/ Imipenem
Pseudomonas aeruginosaPiperacillin/ Tazobactam
Pseudomonas aeruginosaCiprofloxacin
Salmonella, non- typhoid sppAmoxicillin/ Clavulanate Ampicillin/ Amoxicillin
Salmonella, non- typhoid sppCeftriaxoneGentamicin
Salmonella, non- typhoid sppCeftazidime/ Avibactam
Salmonella, non- typhoid sppCeftazidime
Salmonella, non- typhoid sppCefepime
Salmonella, non- typhoid sppMeropenem/ Imipenem
Salmonella, non- typhoid sppPiperacillin/ Tazobactam
Salmonella, non- typhoid sppTMP/SMX
Salmonella, non- typhoid sppCiprofloxacin
Serratia sppCeftazidime/ Avibactam Ceftriaxone Cefuroxime
Serratia sppCefepimeCeftazidime
Serratia sppMeropenem/ Imipenem Piperacillin/ Tazobactam
Serratia sppTMP/SMX
Serratia sppCiprofloxacin
Serratia sppGentamicin
Shigella sppAmoxicillin/ Clavulanate Ampicillin/ AmoxicillinTMP/SMX
Shigella sppCeftriaxoneCefazolin/ Cephalexin
Shigella sppCeftazidime/ Avibactam Cefuroxime
Shigella sppCeftazidime
Shigella sppCefepime
Shigella sppMeropenem/ Imipenem
Shigella sppPiperacillin/ Tazobactam
Shigella sppCiprofloxacin
Stenotrophomonas maltophiliaTMP/SMXCeftazidime/ Avibactam Cefepime
Stenotrophomonas maltophiliaCeftazidimePiperacillin/ Tazobactam
Stenotrophomonas maltophiliaCiprofloxacin
Anaerobic streptococciPenicillin
Anaerobic streptococciAmpicillin/ Amoxicillin
Anaerobic streptococciAmoxicillin/ Clavulanate
Anaerobic streptococciCefazolin
Anaerobic streptococciCefoxitin
Anaerobic streptococciCeftriaxone/ Cefepime
Anaerobic streptococciMeropenem/ Imipenem
Anaerobic streptococciPiperacillin/ Tazobactam
Anaerobic streptococciMetronidazole
Anaerobic streptococciClindamycin
Anaerobic streptococciVancomycin
Bacteroides fragilisAmoxicillin/ ClavulanateCefoxitinPenicillin
Bacteroides fragilisMeropenem/ ImipenemClindamycinAmpicillin/ Amoxicillin
Bacteroides fragilisPiperacillin/ Tazobactam
Bacteroides fragilisMetronidazole
Clostridia (eg, tetani, perfringens)PenicillinCefoxitinCeftriaxone/ Cefepime
Clostridia (eg, tetani, perfringens)Ampicillin/ AmoxicillinClindamycin
Clostridia (eg, tetani, perfringens)Amoxicillin/ Clavulanate
Clostridia (eg, tetani, perfringens)Meropenem/ Imipenem
Clostridia (eg, tetani, perfringens)Piperacillin/ Tazobactam
Clostridia (eg, tetani, perfringens)Metronidazole
Clostridia (eg, tetani, perfringens)Vancomycin
Clostridium difficileMeropenem/ Imipenem
Clostridium difficileMetronidazole
Clostridium difficileVancomycin

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